Werner & Ingbar's The Thyroid

Werner & Ingbar's The Thyroid

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Publication Date: 2012
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ISBN/ISSN: 9781451120639

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Werner & Ingbar’s The Thyroid: A Fundamental and Clinical Text, 10th Edition has been extensively revised and streamlined to deliver the most comprehensive coverage of the thyroid including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Entirely new chapters on the surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs are in this edition. New authors and an international group of contributors elevate this classic text that includes extensive clinical coverage of thyroid dysfunction’s effects on other organ systems. Also addressed are clinical controversies regarding the ageing thyroid, subclinical hypothyroidism and hyperthyroidism and thyroid disease in pregnancy.

New to this edition:

·         Twenty-three chapters authored by new contributors and international experts

·         A companion website with fully searchable text for quick reference

·         Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field


“This is an update of the classic thyroid text and is clearly essential for endocrinologists and thyroid surgeons. It is certainly useful for those undertaking thyroid related research but it is clearly far too detailed for students other than those undertaking basic science research in the thyroid. This edition has added the surgical management of thyroid disorders which is clearly an asset for the endocrine surgeon. With this type of reference text it is inevitable that there will be information from many years ago cited. There has however been a clear effort to update information and expand detail including more up-to-date references — studies related to markers of disease progression in thyroid cancer, cytopathology of thyroid cancer. Studies and other works that are references are of high quality and in general integral to the subject matter being discussed. There has also been a clear effort made to critically appraise the texts being cited. In general it is well written. Sections of the book can be a little monotonous only due to the subject matter i.e. thyroid hormone synthesis and thyroglobulin structure, function and biosynthesis. The diagrams and illustrations particularly in the basic science section are very useful. The use of colour images would have made them a lot more pleasing on the eye. Only for those subspecializing in thyroid disorders or conducting research into the thyroid gland. This book has helped me to understand the thyroid gland further and will continue to do so. It is the type of book one consults to answer a specific question and to provide context for a clinical problem.” — BMA Medical Book Award reviewer, 2013 BMA Medical Book Awards


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New to this edition:

·         Twenty-three chapters authored by new contributors and international experts

·         A companion website with fully searchable text for quick reference

·         Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field

Lewis E. Braverman MD
Professor of Medicine, Boston University School of Medicine; Chief, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston Medical Center, Boston, MA

David Cooper
University of New South Wales, Sydney, Australia


Edition: 10
ISBN/ISSN: 9781451120639
Product Format: Hardbound
Trim Size: 8.375 x 10.875
Pages: 912
Pub Date: 2012
Weight: 5.7

SECTION I. THE NORMAL THYROID

 

PART A. HISTORY, DEVELOPMENT, ANATOMY

 

Chapter 1 The Heritage of the Thyroid: A Brief History

Clark T. Sawin

 

Chapter 2 Development of the Hypothalamic–Pituitary–Thyroid Axis

Pilar Santisteban

 

Chapter 3 Anatomy and Pathology of the Thyrotrophs

Fabio Rotondo, Kalman Kovacs, and Eva Horvath

 

PART B. THYROID HORMONE SYNTHESIS AND SECRETION

 

Chapter 4A Thyroid Hormone Synthesis: Thyroid Iodide Transport

Nancy Carrasco

 

Chapter 4B Thyroid Hormone Synthesis

Peter Kopp

 

Chapter 5 Thyroglobulin Structure, Function, and Biosynthesis

Héctor M. Targovnik

 

PART C. PERIPHERAL THYROID HORMONE BINDING AND METABOLISM

 

Chapter 6 Thyroid Hormone Transport Proteins and the Physiology of Hormone Binding

Salvatore Benvenga

 

Chapter 7 Intracellular Pathways of Iodothyronine Metabolism/Implications of Deiodination for Thyroid Hormone Action

Antonio C. Bianco and Brian W. Kim

 

PART D. THYROID HORMONE ACTION

 

Chapter 8 Genomic and Nongenomic Actions of Thyroid Hormones

Paul M. Yen and Gregory A. Brent

 

Chapter 9 Thyroid Hormone Structure–Function Relationships

Stephen D. Ayers, John D. Baxter, and Paul Webb

 

PART E. FACTORS THAT CONTROL THYROID FUNCTION

 

Chapter 10A Chemistry and Biosynthesis of Thyrotropin

Ronald N. Cohen and Fredric E. Wondisford

 

Chapter 10B The Thyrotropin Receptor

Gilbert Vassart

 

Chapter 10C Regulation of Thyrotropin Secretion

Anthony N. Hollenberg

 

Chapter 11A Age Related Changes in Thyroid Function

Laura Boucai and Martin I. Surks

 

Chapter 11B Effects of Drugs on TSH Secretion, Thyroid Hormones Absorption, Synthesis, Metabolism, and Action

S´ebastien Thalmann and Christoph A. Meier

 

Chapter 11C Nonthyroidal Illness Syndrome

Wilmar M. Wiersinga and Greet Van den Berghe

 

Chapter 11D Iodine Deficiency and Endemic Cretinism

Michael Zimmerman

 

Chapter 11E Effect of Excess Iodide: Clinical Aspects

Elio Roti and Apostolos G. Vagenakis

 

 

SECTION II. ASSESSMENT OF THYROID STRUCTURE AND FUNCTION

 

Chapter 12 Thyroid Radionuclide Uptake and Imaging Studies

Richard L. Wahl

 

Chapter 13A Measuring Serum Thyroid–Stimulating Hormone, Thyroid Hormones, Thyroid-Directed Antibodies, and Transport Proteins

Offie P. Soldin

 

Chapter 13B Measurement of Thyroglobulin

Carole Ann Spencer

 

Chapter 14 Nonisotopic Techniques of Thyroid Imaging

Laszlo Hegedu¨ s and Finn Noe Bennedbaek

 

Chapter 15 Physical Examination of the Thyroid Gland

James V. Hennessey

 

Chapter 16 Pathology and Cytopathology

Zubair Wahid Baloch and Virginia A LiVolsi

 

 

SECTION III. THYROID DISEASES: THYROTOXICOSIS

 

Chapter 17 Introduction to Thyrotoxicosis

Lewis E. Braverman and David S. Cooper

 

PART A. CAUSES OF THYROTOXICOSIS

 

Chapter 18A Pathogenesis of Graves’ Disease

Terry F. Davies

 

Chapter 18B Ophthalmopathy

Petros Perros and Jane Dickinson

 

Chapter 18C Thyroid Dermopathy and Thyroid Acropachy

Vahab Fatourechi

 

Chapter 19 Thyrotropin-Induced Thyrotoxicosis

Paolo Beck-Peccoz and Luca Persani

 

Chapter 20 Toxic Adenoma and Toxic Multinodular Goiter

Ralf Paschke

 

Chapter 21 Trophoblastic Tumors

Jerome M. Hershman

 

Chapter 22 Sporadic Painless, Painful Subacute and Acute Infectious Thyroiditis

Alan P. Farwell

 

Chapter 23 Thyrotoxicosis of Extrathyroid Origin

Angela M. Leung and Joshua D. Safer

 

PART B. ORGAN SYSTEM MANIFESTATIONS

 

Chapter 24 Overview of the Clinical Manifestations of Thyrotoxicosis

Henry B. Burch

 

Chapter 25 The Cardiovascular System in Thyrotoxicosis

Irwin Klein and Sara Danzi

 

Chapter 26 Thyroid Hormones in Thermogenesis, Intermediary Metabolism, and Obesity

Thomas Reinehr

 

Chapter 27 The Male and Female Reproductive System in Thyrotoxicosis

Gerasimos E. Krassas and Nikolaos Pontikides

 

Chapter 28 The Skeletal System in Thyrotoxicosis

Graham R. Williams

 

Chapter 29 Behavioral and Psychiatric Aspects of Thyrotoxicosis

Michael Bauer, Mary Samuels, and Peter C. Whybrow

 

Chapter 30 Thyrotoxic Storm

Leonard Wartofsky

 

PART C. DIAGNOSIS AND MANAGEMENT OF THYROTOXICOSIS

 

Chapter 31 Diagnosis of Thyrotoxicosis

Paul W. Ladenson

 

Chapter 32 Treatment of Thyrotoxicosis

David S. Cooper

 

Chapter 33 Subclinical Thyrotoxicosis

Douglas S. Ross

 

 

SECTION IV. THYROID DISEASES: HYPOTHYROIDISM

 

Chapter 34 Introduction to Hypothyroidism

Lewis E. Braverman and David S. Cooper

 

PART A. CAUSES OF HYPOTHYROIDISM

 

Chapter 35 Chronic Autoimmune Thyroiditis

Anthony P. Weetman

 

Chapter 36 Genetic Defects Causing Hypothyroidism

Thomas Vulsma and Jan J.M. de Vijlder

 

Chapter 37 Primary Hypothyroidism Due to Other Causes

Peter A. Singer

 

Chapter 38 Central Hypothyroidism

Luca Persani and Paolo Beck-Peccoz

 

PART B. ORGAN SYSTEM MANIFESTATIONS OF HYPOTHYROIDISM

 

Chapter 39 Overview of the Clinical Manifestations of Hypothyroidism

Michael T. McDermott

 

Chapter 40 The Cardiovascular System in Hypothyroidism

Irwin Klein and Sara Danzi

 

Chapter 41 The Male and Female Reproductive System in Hypothyroidism

Gerasimos E. Krassas and Nikolaos Pontikides

 

Chapter 42 The Skeletal System in Hypothyroidism

Graham R. Williams

 

Chapter 43 Psychiatric and Cognitive Effects of Hypothyroidism

Kathryn G. Schuff, Mary H. Samuels, Peter C. Whybrow, and Michael Bauer

 

Chapter 44 Myxedema Coma

Leonard Wartofsky

 

PART C. MANAGEMENT OF HYPOTHYROIDISM

 

Chapter 45 Diagnosis of Hypothyroidism

Paul W. Ladenson

 

Chapter 46 Treatment of Hypothyroidism

Jacqueline Jonklaas

 

Chapter 47 Subclinical Hypothyroidism

Douglas Ross

 

 

SECTION V. THYROID DISEASES: NONTOXIC DIFFUSE AND MULTINODULAR GOITER

 

Chapter 48 Multinodular Goiter: Pathogenesis and Management

Hans Graf

 

Chapter 49 Clinical Evaluation and Management of Thyroid Nodules

Susan J. Mandel, Jill E. Langer, and Michael M. Kaplan

 

 

SECTION VI. THYROID CANCERS

 

Chapter 50A Carcinomas of Follicular Epithelium: Epidemiology and Pathogenesis

Arthur B. Schneider and Alina V. Brenner

 

Chapter 50B Molecular Genetics of Tumors of Thyroid Follicular Cells

James A. Fagin and Yuri Efimovich Nikiforov

 

Chapter 50C Carcinoma of the Follicular Epithelium: Surgical Therapy

Gregory W. Randolph and Gerard M. Doherty

 

Chapter 50D Staging and Prognosis of Differentiated Thyroid Cancer

Richard Kloos

 

Chapter 50E Medical Management of Differentiated Epithelial Cell Thyroid Cancer

Sebastiano Filetti, R. Michael Tuttle, and Steven I. Sherman

 

Chapter 51 Medullary Thyroid Carcinoma

Mimi I. Hu, Camilo Jimenez, Gilbert J. Cote, and Robert F. Gagel

 

Chapter 52 Anaplastic Thyroid Cancer and Miscellaneous Tumors of the Thyroid

Joshua P. Klopper, Madeleine A. Kane, and Bryan R. Haugen

 

 

SECTION VII. THE THYROID IN INFANCY AND CHILDHOOD

 

Chapter 53 The Maturation of Thyroid Function in the Perinatal Period and During Childhood

Delbert A. Fisher and Rosalind S. Brown

 

Chapter 54A Hypothyroidism in Infants and Children:Neonatal Screening

Guy Van Vliet and Johnny Deladoey

 

Chapter 54B Hypothyroidism in Infants and Children:

Congenital Hypothyroidism

Guy Van Vliet and Johnny Deladoey

 

Chapter 54C Hypothyroidism in Infants, Children, and Adolescents: Acquired Hypothyroidism

Guy Van Vliet and Johnny Deladoey

 

Chapter 55 Hyperthyroidism in the Neonatal Period and Childhood

Stephen H. LaFranchi and Cheryl E. Hanna

 

 

SECTION VIII. SPECIAL TOPICS IN THYROIDOLOGY

 

Chapter 56 Thyroid Disorders During Pregnancy and Postpartum

John H. Lazarus and Jorge H. Mestman

 

Chapter 57 Thyroid Disruptors

Elizabeth N. Pearce

 

Chapter 58 Reduced Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism, and Action

Alexandra M. Dumitrescu and Samuel Refetoff


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