Foye's Principles of Medicinal Chemistry

Foye's Principles of Medicinal Chemistry

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Publication Date: 2012
Availability: In Stock
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ISBN/ISSN: 9781609133450

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Acclaimed by students and instructors alike, Foye's Principles of Medicinal Chemistry is now in its Seventh Edition, featuring updated chapters plus new material that meets the needs of today's medicinal chemistry courses. This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy.

All the chapters have been written by an international team of respected researchers and academicians. Careful editing ensures thoroughness, a consistent style and format, and easy navigation throughout the text.

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  • New! Membrane Drug Transporters chapter
  • New! Nutrition and Obesity chapter
  • Expanded Anesthetics chapter
  • Abbreviations list includes full terms spelled out
  • Clinical Scenarios: an initial scenario is introduced at the beginning of each chapter. Then, applying the material presented and drugs discussed in the chapter, an Outcome and Chemical Analysis of the Scenario is provided at the end of the chapter.
  • Sidebar boxes provide additional information related to material discussed within the text.
  • Clinical Significance boxes explain how chapter content is related to effective pharmaceutical care.
  • Case Studies at the end of each chapter ask students to evaluate a patient and apply knowledge of medicinal chemistry to choose the most appropriate therapeutic option. 
Victoria F. Roche PhD
Senior Associate Dean, School of Pharmacy and Health Professions, Creighton University, Omaha, NE

Thomas L. Lemke PhD
Associate Dean for Professional Programs and Professor of Medicinal Chemistry, University of Houston, Houston, TX

S. William Zito PhD
College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY

David A. Williams PhD
Emeritus Professor of Chemistry, Massachusetts College of Pharmacy and Health Sciences, Boston, MA


Edition: 7
ISBN/ISSN: 9781609133450
Product Format: Hardbound
Trim Size: 8.375 x 10.875
Pages: 1520
Pub Date: 2012
Weight: 7.3
Historical Perspective of Medicinal Chemistry 
                JOHN L. NEUMEYER
PART I: PRINCIPLES OF DRUG DISCOVERY
Chapter 1 Drug Discovery from Natural Products
                A. DOUGLAS KINGHORN
Chapter 2 Drug Design and Relationship of Functional Groups to Pharmacologic Activity
                JAMES J. KNITTEL
Chapter 3 Molecular Modeling and In Silico Drug Design 
                ROBERT J. DOERKSEN
Chapter 4 Role of Physicochemical Properties and Pharmacokinetics in Drug Discovery
                SUNIL S. JAMBHEKAR
Chapter 5 Drug Metabolism
DAVID A. WILLIAMS
Chapter 6 Membrane Drug Transporters
                MARILYN MORRIS
Chapter 7 Pharmaceutical Biotechnology
                RONALD E. REID
Chapter 8 Receptors as Targets for Drug Discovery  
                TIMOTHY A. MAHER AND DAVID A. JOHNSON
Chapter 9 Drug Discovery Through Enzyme Inhibition 
                STEPHEN KERR
PART II: DRUG RECEPTORS AFFECTING NEUROTRANSMISSION AND ENZYMES AS CATALYTIC RECEPTORS
Chapter 10 Cholinergic Receptors and Drugs Affecting Cholinergic Neurotransmission 
E. KIM FIFER
Chapter 11 Adrenergic Receptors and Drugs Affecting Adrenergic neurotransmission 
                ROBERT K. GRIFFITH
Chapter 12 Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission
RICHARD A. GLENNON AND MALGORZATA DUKAT-GLENNON
Chapter 13 Amino Acid Neurotransmitters and Drugs Affecting Amino Acid Neurotransmission 
                TIMOTHY J. MAHER
PART III: PHARMACODYNAMIC AGENTS
Section 1: Drugs Affecting Central Nervous System
Chapter 14 Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents
RAYMOND G. BOOTH
Chapter 15 Psychotherapeutic Drugs: Antipsychotic and Anxiolytics
                RAYMOND G. BOOTH
Chapter 16 Sedative-Hypnotics 
NADER H. MONIRI
Chapter 17 Anesthetics : General and Local Anesthetics  
                TIMOTHY J. MAHER and MATTHIAS C. LU
Chapter 18 Antiseizure Agents
                BARBARA LEDUC
Chapter 19 Antidepressants 
                DAVID A. WILLIAMS
Chapter 20 CNS Stimulants and Drugs of Abuse
                RICHARD A. GLENNON
Chapter 21 Opioid Analgesics
                CHRISTOPHER   MCCURDY
Section 2: Drugs Affecting the Cardiovascular System
Chapter 22 Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs
AHMED S. MEHANNA
Chapter 23 Diuretics
PETER HARVISON
Chapter 24 Angiotensin-Converting Enzyme Inhibitors, Antagonists and Calcium Blockers
MARC HARROLD
Chapter 25 Central and Peripheral Sympatholytics and Vasodilators
DAVID A. WILLIAMS
Chapter 26 Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis
MARC HARROLD
Chapter 27 Antithrombotics, Thrombolytics, Antiplatelets, and Coagulants,
MATTHIAS C. LU and Thomas Lemke
 Section 3: Drugs Affecting the Hormonal Systems
Chapter 28 Drugs for the Treatment of Diabetes
                S William Zito
Chapter 29 Adrenocorticoids
DUANE D. MILLER, ROBERT W. BRUEGGEMEIER AND JAMES T. DALTON
Chapter 30 Thyroid Function and Thyroid Drugs
ALI R. BANIJAMALI
Chapter 31 Calcium Homeostasis
ROBIN M. ZAVOD
Section 4: Drugs Affecting Inflammation and the Immune Systems
Chapter 32 Nonsteroidal Anti-Inflammatory Drugs
RONALD BORNE
Chapter 33 Antihistamines and Related Antiallergic and Antiulcer Agents
WENDEL L.NELSON
Section 5: Chemotherapeutic Agents
Chapter 34 Antibiotics and Antimicrobial Agents
ELMER J. GENTRY
Chapter 35 Antiparasitic Agents
THOMAS L. LEMKE
Chapter 36 Antifungal Agents
ROBERT K. GRIFFITH
Chapter 37 Antimycobacterial Agents
THOMAS L. LEMKE
Chapter 38 Cancer and Chemotherapy
VICTORIA F. ROCHE
Chapter 39 Antiviral Agents and Protease Inhibitors
                PATRICK WOOSTER
PART IV: DISEASE STATE MANAGEMENT
Chapter 40 Asthma and Chronic Obstructive Pulmonary Disease 1230
S. WILLIAM ZITO
Chapter 41 Men’s Health
DUANE D. MILLER, ROBERT W. BRUEGGEMEIER, AND JAMES T. DALTON
Chapter 42 Women’s Health
ROBIN M. ZAVOD
Chapter 43 Obesity and Nutrition
                THOMAS LEMKE AND DAVID WILLIAMS
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