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Case Study of the Month Quiz

Case Study of the Month

Source: BRS Biochemistry and Molecular Biology, 4th edition Todd A. Swanson, Sandra I. Kim, Marc J. Glucksman, editors Lippincott Williams & Wilkins, 2007 Question List: 1. P. 430, Question 24 2. P. 437, Question 75 3. P. 438, Question 83 4. P. 440-441, Question 99 5. p. 433, Question 42

1) A 35-year-old male has been on the Atkins diet and has been taking in a large protein load. In the small intestine, which of the following enzymes is responsible for cleaving proteins at peptide bonds in which the carboxyl group is contributed by arginine or lysine?
a) Trypsin
b) Chymotrypsin
c) Carboxypeptidase A
d) Carboxypeptidase B
e) Aminopeptidases

2) A 13-year-old boy presents with painful burning in his hands and feet, as well as lipid globules in his urine. He has an abnormally low level of the a-galactosidase A enzyme, and he is diagnosed with Fabry disease. Which of the following accumulates in this patient’s cells?
a) Phosphatidic acid
b) Phospolipases
c) Palmitoyl CoA
d) Sphingosine
e) Glycosphingolipids

3) A 50-year-old male is brought to the emergency room with chest pain and shortness of breath. He is given a medication that activates cGMP, resulting in relaxation of vascular smooth muscle. This medication is most likely a derivative of:
a) Creatine phosphate
b) S-adenosylmethionine
c) Glutathione
d) Melatonin
e) Nitric oxide

4) A 65-year-old male presents with difficulty starting urination, difficulty emptying his bladder, and frequent urination at night. He is diagnosed with benign prostatic hyperplasia, a common condition that causes enlargement of the prostate with resultant compression of the urethra, which inhibits urine from passing out of the bladder. He is prescribed a 5-a-reductase inhibitor called finasteride. Which of the following hormones is mostly likely inhibited by finasteride?
a) Leydig cell secretion of testosterone
b) Sertoli cell production of androgen-binding protein (ABP)
c) Dihydrotestosterone
d) Progesterone
e) Estradiol

5) An infant presents with an enlarged heart, muscle weakness, and hypoventilation. She is diagnosed with glycogen storage disease type 2, a disease causing abnormal glycogen storage in the heart, skeletal muscle, and respiratory muscles. Glycogen synthase is the regulatory enzyme for glycogen synthesis. It adds glucose residues to the nonreducing ends of a glycogen primer from:
a) Glucose 1-phosphate
b) Glucose 6-phosphate
c) UDP-glucose
d) UTP
e) ATP

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