Epilepsy
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Publication Date: 2007
Availability: In Stock
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ISBN/ISSN: 9780781757775

Description

Written and edited by world-renowned authorities, this three-volume work is, to quote a reviewer, "the definitive textbook about seizures and epilepsy". This Second Edition is thoroughly updated and gives you a complete print and multimedia package: the three-volume set plus access to an integrated content Website.

More than 300 chapters cover the spectrum of biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Included are detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; psychiatric and medical comorbidity; conditions that could be mistaken for epilepsy; and an increasing range of pharmacologic, surgical, and alternative therapies, including vagus nerve stimulation and deep brain stimulation. This edition describes many new antiepileptic drugs, major advances in surgical treatment, and state-of-the-art neuroimaging, EEG, and other technologies for diagnosis and seizure prediction.

A companion Website offers instant access to the complete, fully searchable text, plus an image bank of additional figures, video footage, and annual updates to selected chapters.

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--Print and multimedia package: text of Second Edition plus integrated content Website
--Comprehensive coverage from molecular biology to public health concerns in developing countries
--Thorough discussions of epileptic seizure types and epilepsy syndromes
--Detailed descriptions of pharmacotherapy, surgical therapy, and alternative treatments
--Discussions of psychiatric and medical comorbidity
--Detailed discussions of conditions that could be mistaken for epilepsy
--

SECOND EDITION HIGHLIGHTS:

  • A complete print and multimedia package: the three-volume print textbook plus access to an integrated content Website
  • Major advances in understanding basic mechanisms of epilepsy and its consequences have been incorporated
  • Coverage of the latest developments in surgical approaches to treatment, including vagal nerve stimulation
  • Enhanced coverage of neuroimaging and EEG, for diagnosis and seizure prediction
  • Extensive discussion of the many new antiepileptic drugs for managing seizure intensity and frequency, and their side effects
  • New or completely revised chapters: receptor subunits and intracellular mechanisms (in neuronal excitability); updates on seizure types and syndromes as outlined by the International League Against Epilepsy; new information on gelastic seizures; seizure prediction; SPECT imaging; other applications of MRI
Jean Aicardi MD, FRCP
Professor and INSERM Research Director, Department of Child Neurology and Metabolic Disorders, University Hospital Robert Debré, Paris, France

Marc A. Dichter MD, PhD
Professor of Neurology and Pharmacology and David Mahoney Institute of Neurological Sciences, Departments of Neurology and Pharmacology and the University of Pennsylvania School of Medicine, Philadelphia, PA

Timothy A. Pedley MD
Henry and Lucy Moses Professor of Neurology, Chairman, Department of Neurology, Neurologist-in-Chief, Department of Neurology, Columbia University Medical Center, New York, NY; Neurologist-in-Chief, Neurological Institute of New York, Columbia-Presbyterian Medical Center, New York, NY


Edition: 2
ISBN/ISSN: 9780781757775
Product Format: Hardbound
Trim Size: 8.5 x 11
Pages: 3056
Pub Date: 2007
Weight: 15.75

VOLUME I

Introduction: What Is Epilepsy?

SECTION 1 EPIDEMIOLOGY, PATHOLOGY, AND GENETICS OF EPILEPSY

Overview: Epidemiology, Pathology, and Genetics

Epilepsy: Historical PerspectivesNeuropathology

EPIDEMIOLOGY

Incidence and Prevalence

The Natural History and Prognosis ofEpilepsy

NEUROPATHOLOGY

General Neuropathology of Epilepsy

Hippocampal Sclerosis

GENETICS

Genetic Epidemiology

EEG Traits

SECTION II THE NEUROBIOLOGYOF EPILEPSY

Overview: The Neurobiology of Epilepsy

MECHANISMS OF NORMALNEURONAL EXCITABILITY

Control of Neuronal Excitability

Excitatory Synaptic Transmission

Neocortical Anatomy and Physiology

Thalamocortical Anatomy and Physiology

MECHANISMS OF EPILEPTOGENESISAND EPILEPTOGENICITY

Genetic Models of Epilepsy

Seizure Mechanisms and Vulnerability in the Developing Brain

SECTION III PHENOMENOLOGY

Overview: Phenomenology

EPILEPTIC SEIZURES

Simple Motor Seizures

Limbic Seizures

Epileptic Spasms

STATUS EPILEPTICUS

Generalized Convulsive Status Epilepticus

Absence Status Epilepticus

Myoclonic Status Epilepticus

EPILEPTIC DISORDERS

Classification of the Epilepsies

SECTION IV DIAGNOSTICEVALUATION

Overview: Diagnostic Evaluation

ROUTINE INVESTIGATIONS

History and Physical Examination

EEG

Physiologic Basis of the Electroencephalogram and Local Field Potentials

Ictal Electroencephalogram

Polygraphic Recordings

NEUROIMAGING

Positron Emission Tomography

Magnetic Resonance Spectroscopy

Computational Anatomy

NEW DIRECTIONS

Seizure Prediction

Microdialysis

Transcranial Magnetic Stimulation

Cellular Imaging of Epilepsy

NEUROPSYCHOLOGICAL EVALUATION

LONG-TERM MONITORING

VOLUME II

SECTION V GENERALTREATMENT CONSIDERATIONS

Overview: General Approaches toTreatment

GENERAL CONSIDERATIONS

PRINCIPLES OF DRUG TREATMENT

STRATEGIES FORPHARMACOTHERAPY

SPECIAL THERAPEUTICCONSIDERATIONS

ALTERNATIVE APPROACHES

SECTION VI ANTIEPILEPTICDRUGS

ANTIEPILEPTIC DRUG DEVELOPMENT

ANTIEPILEPTIC DRUGS

SECTION VII SURGICAL THERAPY

CANDIDATE SELECTION

INVASIVE MONITORING TECHNIQUES

FUNCTIONAL MAPPING TECHNIQUES

THERAPEUTIC SURGICALPROCEDURES

POSTOPERATIVE FOLLOW-UP

SECTION VIII CLINICAL BIOLOGYOF EPILEPSY>/b>

BIORHYTHMS AND THE AUTONOMICNERVOUS SYSTEM

COMORBIDITY

NEUROENDOCRINOLOGY

VOLUME III

SECTION IX PSYCHIATRIC ANDSOCIAL ISSUES

PSYCHIATRIC ISSUES

SOCIAL ISSUES

SECTION X EPILEPSYSYNDROMES

NEONATAL SYNDROMES

SYNDROMES OF INFANCY AND EARLYCHILDHOOD

SYNDROMES OF LATER CHILDHOODAND ADOLESCENCE

NON AGE-RELATED AND SPECIALSYNDROMES

DISEASES ASSOCIATED WITH EPILEPSY

SECTION XI DISORDERS THATCAN BE CONFUSED WITH EPILEPSY

SYSTEMIC DISTURBANCES

NEUROLOGICAL DISTURBANCES

PSYCHIATRIC DISTURBANCES

SECTION XII DELIVERY OFHEALTH CARE AND SOCIOECONOMIC ISSUES

ORGANIZATION OF HEALTH CARE INDIFFERENT COUNTRIES

SPECIALIZED CENTERS FOR EPILEPSY

COST AND ALLOCATION OFRESOURCES

Subject Index

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