Now celebrating its 20th anniversary, the Sixth Edition of this bestseller continues to offer an unparalleled presentation of the discipline of Pathophysiology. This edition includes the addition of three new chapters: "Concepts of Health and Disease," "Sleep and Sleep Disorders," and "Neurobiology of Thought and Mood Disorders." Essential information is provided, clarifying the interrelationships between normal body functioning to the physiologic changes that participate in disease production and occur as a result of disease, as well as the body's ability to compensate for these changes. Coverage is based on common health problems for all segments of the population, including the special needs of children and elderly persons. An abundance of learning tools--including in-text summaries, chapter outlines, learning objectives, key concept boxes, Internet addresses and extensive explanations--reinforce material and maximize learning potential. This full-color edition, now with seventy-five new illustrations as well as enhancements to existing illustrations, continues to provide visual appeal to facilitate the learning process. Two free Instructors Resource CD-ROMs, including an image bank and a test bank, available to faculty who adopt the text.