Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of the full spectrum of neuropsychiatric disorders.

Nine sections focus on specific groups of disorders--disorders of development; schizophrenia and related disorders; anxiety and stress disorders; affective disorders; Alzheimer's and other dementias; substance use disorders; impulsive and compulsive disorders; movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in detail, including clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation.

Written by a preeminent expert in child and adolescent psychopharmacology, the Third Edition of this acclaimed reference is a current and authoritative clinical guide to the pediatric use of psychotropic drugs. This thoroughly revised edition covers the many new medications that have recently been approved, particularly antidepressants/SSRIs and atypical antipsychotics. Updated chapters on older drugs reflect important new studies, significant changes in recommended use, and new findings about off-label uses. Tables and charts throughout the book summarize practical information. A table on the front pages presents DMS-IV diagnoses, appropriate medications, and corresponding page references in the book.