Histology

A Text and Atlas
Histology 9780781772006
Publication Date: Oct 15, 2010
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Edition: Sixth
ISBN/ISSN: 9780781772006
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Description

Now in its revised, updated Sixth Edition, Histology: A Text and Atlas is ideal for medical, health professions, and undergraduate biology students. This best-selling combination text and atlas includes a detailed textbook description that emphasizes clinical and functional correlates of histology, fully supplemented by vividly informative illustrations and photographs. Separate, superbly illustrated atlas sections follow almost every chapter and feature large-size, full-color digital micrographs, with labels and legends that highlight details of microanatomy.

For this edition, approximately 20 percent of the micrographs have been replaced with newly enhanced, sharper images. One third of the illustrations have been redrawn in a new style.

A powerful online interactive atlas is included with the book and features all of the plates in the text with interactive functionality.

Features

--NEW: Replacement of approximately 20% of the micrograph plates with new, sharper, enhanced images
--NEW: One third of illustrations redrawn in new style (approximately 75 illustrations)
--NEW: Revised and updated chapters
--Clinical correlation boxes
--Micrograph/illustration combinations
--Online Interactive Atlas

About the Author(s)

  • Michael H Ross PhD
  • Professor and Chairman Emeritus, Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL

  • Wojciech Pawlina MD
  • Professor and Chair, Department of Anatomy, Mayo Clinic College of Medicine, Rochester, MN

Specs

  • Edition: Sixth
  • Product Format: Softbound
  • ISBN: 9780781772006
  • Trim Size: 8.375 x 10.875
  • Pages: 928
  • Pub Date: Oct 15, 2010
  • Weight: 5.0

Table of contents

1.

METHODS | 1Overview of Methods Used in Histology

 

 

| 1 | 2Histochemistry and Cytochemistry

| 3Microscopy

| 13Folder 1.1

Clinical Correlation: Frozen Sections | 4Folder 1.2

Microspectrophotometry | 7

Functional Considerations: FeulgenFolder 1.3

Medicine | 9

Clinical Correlation: Monoclonal Antibodies inFolder 1.4

Proper Use of the Light Microscope | 112.

CELL CYTOPLASM | 22Overview of the Cell and Cytoplasm

| 22Membranous Organelles

| 25Nonmembranous Organelles

| 56Inclusions

| 71Cytoplasmic Matrix

| 73Folder 2.1

Diseases | 42

Clinical Correlation: Lysosomal StorageFolder 2.2

Microtubules and Filaments | 68

Clinical Correlation: Abnormalities inFolder 2.3

of Centrioles and Cancer | 72

Clinical Correlation: Abnormal Duplication3.

THE CELL NUCLEUS | 75Overview of the Nucleus

| 75Nuclear Components

| 75Cell Renewal

| 84Cell Cycle

| 86Cell Death

| 93Folder 3.1

Clinical Correlation: Cytogenetic Testing | 80Folder 3.2

and Cancer Treatment | 81

Clinical Correlation: Regulation of Cell Cycle4.

CLASSIFICATION |

TISSUES: CONCEPT AND98Overview of Tissues

| 98Epithelium

| 99Connective Tissue

| 99Muscle Tissue

| 100Nerve Tissue

| 101Histogenesis of Tissues

| 102Identifying Tissues

| 102Folder 4.1

Clinical Correlation: Ovarian Teratomas | 1035.

EPITHELIAL TISSUE | 105Overview of Epithelial Structure and Function

| 105Classification of Epithelium

| 106Cell Polarity

| 107The Apical Domain and its Modifications

| 109The Lateral Domain and its Specializations in

Cell-To-Cell Adhesion

| 121The Basal Domain and its Specializations in

Cell-To-Extracellular Matrix Adhesion

| 134Glands

| 146Epithelial Cell Renewal

| 150Folder 5.1

Clinical Correlation: Epithelial Metaplasia | 109Folder 5.2

Dyskinesia | 120

Clinical Correlation: Primary CiliaryFolder 5.3

as a Target of Pathogenic Agents | 128

Clinical Correlation: Junctional ComplexesFolder 5.4

Membrane and Basal Lamina

Terminology | 138

Functional Considerations: BasementFolder 5.5

Serous Membranes | 150

Functional Considerations: Mucus andAtlas Plates

Plate 1

Epithelia | 152

Simple Squamous and CuboidalPlate 2

Simple and Stratified Epithelia | 154Plate 3

Tissues | 156

Stratified Epithelia and Epithelioid 6.

CONNECTIVE TISSUE | 158General Structure and Function of

Connective Tissue

| 158Embryonic Connective Tissue

| 159Connective Tissue Proper

| 160Connective Tissue Fibers

| 161Extracellular Matrix

| 173Connective Tissue Cells

| 178Folder 6.1

Clinical Correlation: Collagenopathies | 170Folder 6.2

Molecular Changes in Photoaged Skin | 173

Clinical Correlation: Sun Exposure andFolder 6.3

Wound Repair | 183

Clinical Correlation: Role of Myofibroblasts inFolder 6.4

Phagocytotic System | 185

Functional Considerations: The MononuclearFolder 6.5

and Basophils in Allergic Reactions | 188

Clinical Correlation: The Role of Mast CellsAtlas Plates

Plate 4

Tissue | 192

Loose and Dense Irregular ConnectivePlate 5

Ligaments | 194

Dense Regular Connective Tissue, Tendons, andPlate 6

Elastic Fibers and Elastic Lamellae | 1967.

CARTILAGE | 198Overview of Cartilage

| 198Hyaline Cartilage

| 199Elastic Cartilage

| 204Fibrocartilage

| 204Chondrogenesis and Cartilage Growth

| 206Repair of Hyaline Cartilage

| 207Folder 7.1

Clinical Correlation: Osteoarthritis | 199Folder 7.2

the Cartilage; Chondrosarcomas | 208

Clinical Correlation: Malignant Tumors ofAtlas Plates

Plate 7

Hyaline Cartilage | 210Plate 8

Cartilage and the Developing Skeleton | 212Plate 9

Elastic Cartilage | 214Plate 10

Fibrocartilage | 2168.

BONE | 218Overview of Bone

| 218Bones and Bone Tissue

| 219General Structure of Bones

| 220Cells of Bone Tissue

| 223Bone Formation

| 232Biologic Mineralization and Matrix Vesicles

| 241Physiologic Aspects of Bone

| 242Folder 8.1

Clinical Correlation: Joint Diseases | 221Folder 8.2

Clinical Correlation: Osteoporosis | 233Folder 8.3

in Bone Formation | 234

Clinical Correlation: Nutritional FactorsFolder 8.4

Regulation of Bone Growth | 242

Functional Considerations: HormonalAtlas Plates

Plate 11

Bone, Ground Section | 244Plate 12

Bone and Bone Tissue | 246Plate 13

Endochondral Bone Formation I | 248Plate 14

Endochondral Bone Formation II | 250Plate 15

Intramembranous Bone Formation | 2529.

ADIPOSE TISSUE | 254Overview of Adipose Tissue

| 254White Adipose Tissue

| 254Brown Adipose Tissue

| 259Folder 9.1

Clinical Correlation: Obesity | 261Folder 9.2

Clinical Correlation: Adipose Tissue Tumors | 262Folder 9.3

Brown Adipose Tissue Interference | 264

Clinical Correlation: PET Scanning andAtlas Plates

Plate 16

Adipose Tissue | 26610.

BLOOD | 268Overview of Blood

| 268Plasma

| 269Erythrocytes

| 270Leukocytes

| 275Thrombocytes

| 286Formation of Blood Cells (Hemopoiesis)

| 289Bone Marrow

| 298Folder 10.1

Group Systems | 273

Clinical Correlation: ABO and Rh BloodFolder 10.2

with Diabetes | 274

Clinical Correlation: Hemoglobin in PatientsFolder 10.3

Clinical Correlation: Hemoglobin Disorders | 276Folder 10.4

Neutrophils; Chronic Granulomatous Disease

(CGD) | 281

Clinical Correlation: Inherited Disorders ofFolder 10.5

and Jaundice | 281

Clinical Correlation: Hemoglobin BreakdownFolder 10.6

Marrow | 300

Clinical Correlation: Cellularity of the BoneAtlas Plates

Plate 17

Erythrocytes and Granulocytes | 302Plate 18

Agranulocytes and Red Marrow | 304Plate 19

Erythropoiesis | 306Plate 20

Granulopoiesis | 30811.

MUSCLE TISSUE | 310Overview and Classification of Muscle

| 310Skeletal Muscle

| 311Cardiac Muscle

| 327Smooth Muscle

| 331Folder 11.1

and Ischemia | 316

Functional Considerations: Muscle MetabolismFolder 11.2

Dystrophin and Dystrophin- Associated

Proteins | 319

Clinical Correlation: Muscular Dystrophies—Folder 11.3

Filament Model | 323

Functional Considerations: The SlidingFolder 11.4

Clinical Correlation: Myasthenia Gravis | 325Folder 11.5

the Three Muscle Types | 337

Functional Considerations: Comparison ofAtlas Plates

Plate 21

Skeletal Muscle I | 340Plate 22

Skeletal Muscle II and Electron Microscopy | 342Plate 23

Myotendinal Junction | 344Plate 24

Cardiac Muscle | 346Plate 25

Cardiac Muscle, Purkinje Fibers | 348Plate 26

Smooth Muscle I | 35012.

NERVE TISSUE | 352Overview of the Nervous System

| 352Composition of Nerve Tissue

| 353The Neuron

| 353Supporting Cells of the Nervous System;

The Neuroglia

| 363Origin of Nerve Tissue Cells

| 373Organization of the Peripheral Nervous System

| 375Organization of the Autonomic Nervous System

| 378Organization of the Central Nervous System

| 381Response of Neurons to Injury

| 386Folder 12.1

Clinical Correlation: Parkinson’s Disease | 358Folder 12.2

Clinical Correlation: Demyelinating Diseases | 366Folder 12.3

in the CNS | 389

Clinical Correlation: Gliosis: Scar formationAtlas Plates

Plate 27

Sympathetic and Dorsal Root Ganglia | 390Plate 28

Peripheral Nerve | 392Plate 29

Cerebrum | 394Plate 30

Cerebellum | 396Plate 31

Spinal Cord | 39813.

CARDIOVASCULAR SYSTEM | 400Overview of the Cardiovascular System

| 400Heart

| 402General Features of Arteries and Veins

| 408Arteries

| 414Capillaries

| 421Arteriovenous Shunts

| 423Veins

| 424Atypical Blood Vessels

| 426Lymphatic Vessels

| 427Folder 13.1

Clinical Correlation: Atherosclerosis | 411Folder 13.2

Clinical Correlation: Hypertension | 416Folder 13.3

Clinical Correlation: Ischemic Heart Disease | 429Atlas Plates

Plate 32

Heart | 432Plate 33

Aorta | 434Plate 34

Muscular Arteries and Veins | 436Plate 35

Arterioles, Venules, and Lymphatic Vessels | 43814.

LYMPHATIC SYSTEM | 440Overview of the Lymphatic System

| 440Cells of the Lymphatic System

| 441Lymphatic Tissues and Organs

| 453Folder 14.1

Names T Lymphocyte and B Lymphocyte | 447

Functional Considerations: Origin of theFolder 14.2

Reactions | 447

Clinical Correlation: HypersensitivityFolder 14.3

Virus (HIV) and Acquired Immunodeficiency

Syndrome (AIDS) | 455

Clinical Correlation: Human ImmunodeficiencyFolder 14.4

Lymphadenitis | 466

Clinical Correlation: Reactive (Inflammatory)Atlas Plates

Plate 36

Palatine Tonsil | 476Plate 37

Lymph Node I | 478Plate 38

Lymph Node II | 480Plate 39

Spleen I | 482Plate 40

Spleen II | 484Plate 41

Thymus | 48615.

INTEGUMENTARY SYSTEM | 488Overview of the Integumentary System

| 488Layers of the Skin

| 489Cells of the Epidermis

| 493Structures of Skin

| 501Folder 15.1

Origin | 492

Clinical Correlation: Cancers of EpidermalFolder 15.2

Functional Considerations: Skin Color | 499Folder 15.3

and Hair Characteristics | 504

Functional Considerations: Hair GrowthFolder 15.4

Sebum | 505

Functional Considerations: The Role ofFolder 15.5

Disease | 507

Clinical Correlation: Sweating andFolder 15.6

Clinical Correlation: Skin Repair | 512Atlas Plates

Plate 42

Skin I | 514Plate 43

Skin II | 516Plate 44

Apocrine and Eccrine Sweat Glands | 518Plate 45

Sweat and Sebaceous Glands | 520Plate 46

Integument and Sensory Organs | 522Plate 47

Hair Follicle and Nail | 52416.

ORAL CAVITY AND

ASSOCIATED STRUCTURES |

DIGESTIVE SYSTEM I:526Overview of the Digestive System

| 526Oral Cavity

| 527Tongue

| 529Teeth and Supporting Tissues

| 534Salivary Glands

| 545Folder 16.1

of Taste | 533

Clinical Correlation: The Genetic BasisFolder 16.2

Permanent (Secondary) and Deciduous

(Primary) Dentition | 534

Clinical Correlation: Classification ofFolder 16.3

Clinical Correlation: Dental Caries | 547Folder 16.4

Clinical Correlation: Salivary Gland Tumors | 555Atlas Plates

Plate 48

Lip, A Mucocutaneous Junction | 556Plate 49

Tongue I | 558Plate 50

Tongue II - Foliate Papillae and Taste Buds | 560Plate 51

Submandibular Gland | 562Plate 52

Parotid Gland | 564Plate 53

Sublingual Gland | 56617.

ESOPHAGUS AND

GASTROINTESTINAL TRACT |

DIGESTIVE SYSTEM II:568Overview of the Esophagus and Gastrointestinal

Tract

| 569Esophagus

| 572Stomach

| 574Small Intestine

| 586Large Intestine

| 597Folder 17.1

and Peptic Ulcer Disease | 578

Clinical Correlation: Pernicious AnemiaFolder 17.2

Syndrome | 580

Clinical Correlation: Zollinger-EllisonFolder 17.3

Endocrine System | 581

Functional Considerations: The GastrointestinalFolder 17.4

Absorptive Functions of Enterocytes | 587

Functional Considerations: Digestive andFolder 17.5

of the Alimentary Canal | 595

Functional Considerations: Immune FunctionsFolder 17.6

Vessel Distribution and Diseases of the

Large Intestine | 602

Clinical Correlation: The Pattern of LymphAtlas Plates

Plate 54

Esophagus | 606Plate 55

Esophagus And Stomach, Cardiac Region | 608Plate 56

Stomach I | 610Plate 57

Stomach II | 612Plate 58

Gastroduodenal Junction | 614Plate 59

Duodenum | 616Plate 60

Jejunum | 618Plate 61

Ileum | 620Plate 62

Colon | 622Plate 63

Appendix | 624Plate 64

Anal Canal | 62618.

GALLBLADDER, AND PANCREAS |

DIGESTIVE SYSTEM III: LIVER,628Liver

| 628Gallbladder

| 643Pancreas

| 647Folder 18.1

Clinical Correlation: Lipoproteins | 630Folder 18.2

Failure and Liver Necrosis | 635

Clinical Correlation: Congestive HeartFolder 18.3

Disease | 655

Insulin Production and Alzheimer’sFolder 18.4

Synthesis, an Example of

Posttranslational Processing | 655

Functional Considerations: InsulinAtlas Plates

Plate 65

Liver I | 656Plate 66

Liver II | 658Plate 67

Gallbladder | 660Plate 68

Pancreas | 66219.

RESPIRATORY SYSTEM | 664Overview of the Respiratory System

| 664Nasal Cavities

| 665Pharynx

| 670Larynx

| 670Trachea

| 670Bronchi

| 676Bronchioles

| 677Alveoli

| 678Blood Supply

| 687Lymphatic Vessels

| 687Nerves

| 687Folder 19.1

in the Respiratory Tract | 672

Clinical Correlations: Squamous MetaplasiaFolder 19.2

Clinical Correlations: Cystic Fibrosis | 685Folder 19.3

Pneumonia | 686

Clinical Correlations: Emphysema andAtlas Plates

Plate 69

Olfactory Mucosa | 688Plate 70

Larynx | 690Plate 71

Trachea | 692Plate 72

Bronchioles and End Respiratory Passages | 694Plate 73

and Alveolus | 696

Terminal Bronchiole, Respiratory Bronchiole,20.

URINARY SYSTEM | 698Overview of the Urinary System

| 698General Structure of the Kidney

| 699Kidney Tubule Function

| 714Interstitial Cells

| 720Histophysiology of the Kidney

| 720Blood Supply

| 721Lymphatic Vessels

| 723Nerve Supply

| 723Ureter, Urinary Bladder, and Urethra

| 723Folder 20.1

Vitamin D | 699

Functional Considerations: Kidney andFolder 20.2

Membrane Antibody-Induced Glomerulonephritis;

Goodpasture Syndrome | 712

Clinical Correlation: Antiglomerular BasementFolder 20.3

Urine—Urinalysis | 714

Clinical Correlation: Examination of theFolder 20.4

Renin–Angiotensin–Aldosterone System and

Hypertension | 714

Clinical Correlation: 

Function of Aquaporin Water Channels | 717

Folder 20.5 Functional Considerations: Structure andFolder 20.6

Regulation of Collecting Duct Function | 721

Functional Considerations: HormonalAtlas Plates

Plate 74

KIDNEY I | 728Plate 75

KIDNEY II | 730Plate 76

KIDNEY III | 732Plate 77

KIDNEY IV | 734Plate 78

URETER | 736Plate 79

URINARY BLADDER | 73821.

ENDOCRINE ORGANS | 740Overview of the Endocrine System

| 740Pituitary Gland (Hypophysis)

| 742Hypothalamus

| 751Pineal Gland

| 752Thyroid Gland

| 755Parathyroid Glands

| 760Adrenal Glands

| 762Folder 21.1

Pituitary Gland Secretion | 743

Functional Considerations: Regulation ofFolder 21.2

Diseases | 750

Clinical Correlation: Principles of EndocrineFolder 21.3

with ADH Secretion | 753

Clinical Correlation: Pathologies AssociatedFolder 21.4

Clinical Correlation: Abnormal Thyroid Function | 758Folder 21.5

Pheochromocytoma | 766

Clinical Correlation: Chromaffin Cells andFolder 21.6

of Adrenal Hormones | 769

Functional Considerations: BiosynthesisAtlas Plates

Plate 80

Pituitary I | 772Plate 81

Pituitary II | 774Plate 82

Pineal Gland | 776Plate 83

Parathyroid and Thyroid Glands | 778Plate 84

Adrenal Gland I | 780Plate 85

Adrenal Gland II | 78222.

MALE REPRODUCTIVE SYSTEM | 784Overview of the Male Reproductive System

| 784Testis

| 784Spermatogenesis

| 792Seminiferous Tubules

| 798Intratesticular Ducts

| 802Excurrent Duct System

| 803Accessory Sex Glands

| 808Prostate Gland

| 808Semen

| 813Penis

| 813Folder 22.1

Regulation of Spermatogenesis | 788

Functional Considerations: HormonalFolder 22.2

Spermatogenesis | 789

Clinical Correlation: Factors AffectingFolder 22.3

and the Immune Response | 803

Clinical Correlation: Sperm-Specific AntigensFolder 22.4

Hypertrophy and Cancer of the Prostate | 811

Clinical Correlation: Benign ProstaticFolder 22.5

and Erectile Dysfunction | 815

Clinical Correlation: Mechanism of ErectionAtlas Plates

Plate 86

Testis I | 818Plate 87

Testis II | 820Plate 88

Efferent Ductules and Epididymis | 822Plate 89

Spermatic Cord and Ductus Deferens | 824Plate 90

Prostate Gland | 826Plate 91

Seminal Vesicle | 82823.

SYSTEM |

FEMALE REPRODUCTIVE830Overview of the Female Reproductive System

| 830Ovary

| 831Uterine Tubes

| 845Uterus

| 848Placenta

| 854Vagina

| 860External Genitalia

| 861Mammary Glands

| 863Folder 23.1

Disease | 839

Clinical Correlation: Polycystic OvarianFolder 23.2

Clinical Correlation: In Vitro Fertilization | 844Folder 23.3

Hormonal Regulation of the Ovarian Cycle | 846

Functional Considerations: Summary ofFolder 23.4

Placenta at Birth | 860

Clinical Correlation: Fate of the MatureFolder 23.5

Clinical Correlation: Cytologic Pap Smears | 862Folder 23.6

Infections | 868

Clinical Correlation: Cervix and HPVFolder 23.7

Infertility | 870

Functional Considerations: Lactation andAtlas Plates

Plate 92

Ovary I | 872Plate 93

Ovary II | 874Plate 94

Corpus Luteum | 876Plate 95

Uterine Tube | 878Plate 96

Uterus I | 880Plate 97

Uterus II | 882Plate 98

Cervix | 884Plate 99

Placenta I | 886Plate 100

Placenta II | 888Plate 101

Vagina | 890Plate 102

Mammary Gland–Inactive Stage | 892Plate 103

Lactating Stages | 894

Mammary Gland, Late Proliferative and24.

EYE | 896Overview of the Eye

| 896General Structure of the Eye

| 896Microscopic Structure of the Eye

| 899Folder 24.1

Clinical Correlation: Glaucoma | 905Folder 24.2

Clinical Correlation: Retinal Detachment | 908Folder 24.3

Degeneration (ARMD) | 909

Clinical Correlation: Age-Related MacularFolder 24.4

Clinical Correlation: Conjunctivitis | 917Atlas Plates

Plate 104

Eye I | 920Plate 105

Eye II: Retina | 922Plate 106

Eye III: Anterior Segment | 924Plate 107

Eye IV: Sclera, Cornea, and Lens | 92625.

EAR | 928Overview of the Ear

| 928External Ear

| 928Middle Ear

| 929Internal Ear

| 932Folder 25.1

Clinical Correlation: Otosclerosis | 933Folder 25.2

Dysfunction | 934

Clinical Correlation: Hearing Loss—VestibularFolder 25.3

Clinical Correlation: Vertigo | 937Atlas Plates

Plate 108

Ear | 946Plate 109

Cochlear Canal and Organ of Corti | 948Index | 950

 

 

Tissue Preparation

Preface | vii

Acknowledgments | ix